The cause of diabetic nephropathy

Diabetic nephropathy is caused by different etiology and pathogenesis of insulin in the absolute and relative lack of sugar and protein metabolism and fat metabolism, and chronic hyperglycemia as the main clinical

Performance of the systemic disease. Diabetes can damage the kidneys in different ways. These lesions can all affect the structure of the kidneys, but only glomerulosclerosis is directly related to diabetes

, Also known as diabetic nephropathy, is one of the diabetic systemic microvascular complications. Diabetic patients in the event of renal damage occurs persistent proteinuria is irreversible often

Development to end-stage renal failure. Diabetic nephropathy has become a major cause of death in diabetic patients.
Diabetic nephropathy more common in the course of more than 10 years of diabetes, proteinuria is the earliest performance of diabetic nephropathy, the pathogenesis is very complex, not yet fully elucidated. Research data

The pathogenesis of diabetic nephropathy is a multi-factor, mainly in the following areas:
1, renal hemodynamic abnormalities
In the occurrence of diabetic nephropathy, play a key role, and may even be the starting factor.
(1) hyperglycemia, glomerular hyperperfusion, high filtration state, increased pressure across the capillary wall, the expansion of mesangial cells, epithelial cell fossa fusion and produce dense droplets, kidney

The pellet epithelial cells fall off the basement membrane. (2) glomerular basement membrane type Ⅳ collagen messenger sugar nucleic acid increased, so that the basement membrane thickening, and ultimately the formation of diffuse mesangial, nodular lesions, hair

Glomerular sclerosis. (3) in the case of increased pressure, protein filtration increased, can also be deposited in the mesangial area and glomerular basement membrane, promote matrix proliferation, the formation of a vicious circle, and

Can cause nodular and diffuse glomerular sclerosis.
2, hyperglycemia
Diabetic nephropathy
Diabetes Nephrology Atlas
Diabetic nephropathy and hyperglycemia are closely related to poor blood glucose control can accelerate the development of diabetic nephropathy, good blood glucose control can significantly delay its development. High blood sugar and sugar

Alkaline end product production increased after mesangial cell proliferation, increased extracellular matrix, mesangial expansion, glomerular basement membrane thickening and so on.
3, genetic factors
Most patients with diabetes will eventually do not have kidney disease, some long-term good blood glucose control in patients with diabetes can also be the same disease. Glucose Transporter 1 (GLUT1) is

Major Glucose Transporters on Glomerular Mesangial Cells. Recent studies have found that diabetic patients with different individuals between the mesangial cells GLUT1 menu up to the difference in regulation may be

Is part of the patients susceptible to kidney damage one of the factors. And the occurrence of diabetic nephropathy also showed family aggregation phenomenon, in some family history of diabetes with diabetes,

The incidence of diabetic nephropathy was also significantly higher than that of patients without family history of hypertension. In addition, the incidence of diabetic nephropathy among different races is also different. This is all that sugar

The incidence of nephropathy is related to genetic factors.
4, high blood pressure
And diabetic nephropathy has no direct relationship, but the original high blood pressure or duration to microalbuminuria when the blood pressure can accelerate the progress of diabetic nephropathy and renal function deterioration,

Increased urinary albumin discharge.