How to treat allergic purpura nephritis? What is the prognosis?

Most patients with Henoch-Schonlein purpura nephritis have a tendency to self-limiting, mild symptoms, no special treatment. But in the acute phase should pay attention to warm, bed rest, disable all suspicious allergies and food, avoid contact with suspicious allergens. If there are allergic symptoms available anti-allergic drugs (such as chlorpheniramine, diphenhydramine, Astemizole, etc.) symptomatic treatment. Other symptomatic treatments include anti-infective, lower blood pressure and diuretic therapy.

How to treat allergic purpura nephritis? What is the prognosis?

Glucocorticoids on joint swelling and pain, abdominal pain and gastrointestinal symptoms have a certain therapeutic effect, generally with prednisone 1-2mg · kg_1. D_1, with 1-2 weeks can be. For severe skin purpura can be treated with hydrocortisone or succinic hydrocortisone. Generally believed that the damage to the kidneys no significant effect, can not change the course of allergic purpura nephritis and prognosis, can not prevent the recurrence of purpura. However, patients with acute nephritis syndrome, allergic purpura nephritis patients should be considered timely use of high-dose methylprednisolone impact treatment, and to anticoagulant and anti-platelet aggregation treatment, about half of the patients treated effectively. Some people think that the performance of nephrotic syndrome, allergic purpura nephritis patients should adopt hormone therapy, although the effect is not as good as primary nephrotic syndrome, but the swelling, reduce proteinuria or have a certain effect. Cytotoxic drugs such as cyclophosphamide treatment effect is not yet sure. Allergic purple paralysis nephritis of traditional Chinese medicine treatment to blood circulation, detoxification based.



The efficacy of allergic purpura nephritis is closely related to the type of clinical manifestations and the degree of pathological changes. Mild lesions and acute nephritis type of good effect, and chronic nephritis type effect is poor; pathological changes to ⅱ ,, ⅲ type of treatment is better. And iv, v-type treatment is poor. Pathological changes in the class IV above should pay attention to the protection of renal function.

The prognosis of patients with Henoch-Schonlein purpura nephritis is closely related to the pathological changes of the kidneys. According to incomplete statistics, about 52% of patients in the onset of a year can be completely relieved, 15% can persist in the presence of gross hematuria and domain proteinuria (1g / day), 18% of patients with persistent hematuria And micro-proteinuria, no glomerular filtration rate decreased, only 5% of patients in a few years can progress to chronic renal insufficiency. Some patients were followed up for 10 years and found that 70% -80% of patients had complete remission, 15% had persistent renal disease, 8% had renal insufficiency, and only 1% died The ,

The main factors affecting the prognosis of allergic purpura nephritis are: ① age: the prognosis of children with better prognosis, adult patients with poor prognosis; ② clinical manifestations: the performance of a large number of proteinuria and hypertension associated with poor prognosis; Pathological changes: 40% of patients with more than 40 patients can progress to chronic renal insufficiency, and only 3% of patients below type iii can progress to chronic renal insufficiency; with subepithelial and subcutaneous immune complex deposition Of the patients, the immune complex is limited to the glomerular mesangial area of ​​the prognosis is poor.