What are the reasons for high creatinine?

When the glomerular filtration rate dropped to normal more than 50%, serum creatinine began to rise rapidly, so when the serum creatinine was significantly higher than normal, often that renal function has been seriously damaged.
  Creatinine is too high, to a large extent that renal function decreased. And renal function - renal detoxification function decline, because the patient's kidney function cells due to various causes of persistent disease factors, morphological changes, functional damage, or even completely necrosis. And because the ability of the kidney is very strong, even if the loss of a kidney, the rest of the kidneys can also complete the task of detoxification of the human body, including serum creatinine levels, including a variety of laboratory indicators are naturally normal. This means that once the high incidence of serum creatinine phenomenon, then the degree of damage to the kidneys have been very serious. It is recommended that you go to the regular hospital as soon as possible for further examination and treatment.